Synthesis of rose like structured LaCoO3 assisted functionalized carbon nanofiber nanocomposite for efficient electrochemical detection of anti-inflammatory drug 4-aminoantipyrine

• Published in: Electrochimica acta 2018-01, Vol.260, p.571-581
• Main Authors: Sakthivel, Mani, Ramaraj, Sukanya, Chen, Shen-Ming, Dinesh, Bose
• Format: Article
• Language: English
• Subjects: 4-Aminoantipyrine (4-AAP); Carbon nanofiber (CNF); Electrochemical sensor; Lanthanum cobalt oxide (LaCoO3); Non-steroid anti-inflammatory drug; Perovskite material
• ISSN: 0013-4686; 1873-3859
• DOI: 10.1016/j.electacta.2017.11.122

For the first time, lanthanum cobalt oxide was prepared in a rose like structure and assisted with functionalized carbon nanofiber (f-CNF/LaCoO3) using the hydrothermal technique. Further, the prepared f-CNF/LaCoO3 was used as an electrode material for sensitive electrochemical detection of non-steroid anti-inflammatory drug 4-Aminoantipyrine (4-AAP). The formation of f-CNF/LaCoO3 nanocomposite was characterized by using various analytical techniques including scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). In addition, electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and amperometric i-t technique were performed to scrutinize the electrochemical activity of f-CNF/LaCoO3/GCE toward the electrochemical oxidation of 4-AAP. The proposed sensor exhibits excellent electrochemical performance with wide linear range (0.001–1374.87 μM) and ultra low detection limit of as low as concentration (1.0 nM) of 4-AAP. Moreover, the excellent selectivity of the sensor was recorded and the practicability of the sensor also demonstrated for detection of 4-AAP in the human urine sample. •First time, a novel perovskite type lanthanum cobalt oxide (LaCoO3) with defined rose like structure was prepared and successfully assisted with functionalized carbon nanofiber (f-CNF) using simple hydrothermal technique.•The as synthesized f-CNF/LaCoO3 nanocomposite modified GCE was used as an effective electrode material for electrochemical detection of non-steroid anti-inflammatory drug 4-Aminoantipyrine (4-AAP).•The reported f-CNF/LaCoO3/GCE sensor exhibits ultra-low detection limit (1 nm) of 4-AAP.•The excellent practicability of f-CNF/LaCoO3/GCE towards the detection of 4-AAP in human urine sample was also studied.