Supplementation with omega-3 fatty acids and plasma adiponectin in women with polycystic ovary syndrome

• Published in: Endocrinología, diabetes y nutrición. diabetes y nutrición., 2018-04, Vol.65 (4), p.192-199
• Main Authors: Mejia-Montilla, Jorly, Reyna-Villasmil, Eduardo, Domínguez-Brito, Lorena, Naranjo-Rodríguez, Carmen, Noriega-Verdugo, Delia, Padilla-Samaniego, María, Vargas-Olalla, Vanessa
• Format: Article
• Language: English
• Subjects: Adiponectin; Adiponectina; Endocrinology and Metabolism; Omega-3; Polycystic ovary syndrome; Suplementación; Supplementation; Síndrome de ovario poliquístico
• ISSN: 2530-0180; 2530-0180
• DOI: 10.1016/j.endien.2018.04.006

Abstract Objective To study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements. Patients and methods A study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12 weeks (n = 97; group A) and control women given placebo (n = 98, group B). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared. Results There were no significant differences between the two groups in general characteristics. No significant differences were also found in hormone, blood glucose, and HOMA levels between the groups. Women in study groups A and B showed no statistically significant differences in total calorie, carbohydrate, protein, and total fat intake between the baseline and final values. Decreased total cholesterol, low-density lipoprotein, and triglyceride levels were found in group A women ( p < 0.0001). Mean of adiponectin levels also showed a statistically significant increase after treatment ( p < 0.0001). There were no statistically significant differences in the mean values of the different variables in group B women. Conclusion Omega-3 fatty acid supplementation for 12 weeks caused a significant increase in plasma adiponectin levels in women with polycystic ovary syndrome.