Follow-up and results in patients with differentiated thyroid carcinoma in Castilla-La Mancha (2001–2015). The CADIT-CAM study

• Published in: Endocrinología, diabetes y nutrición. diabetes y nutrición., 2019-03, Vol.66 (3), p.164-172
• Main Authors: Sastre Marcos, Julia, Aznar, Silvia, Álvarez, Visitación, Torres, Belvis, Delgado, Manuel, González, Javier, Quiroga, Iván
• Format: Article
• Language: English
• Subjects: Carcinoma diferenciado de tiroides; Castilla-La Mancha; Differentiated thyroid carcinoma; Endocrinology and Metabolism; España; Spain
• ISSN: 2530-0180; 2530-0180
• DOI: 10.1016/j.endien.2018.10.010

Abstract Objective The CADIT-CAM study was designed to retrospectively analyze the clinical characteristics, treatments, and outcomes of patients with differentiated thyroid carcinoma (DTC) in Castilla La Mancha. Patients and methods A total of 1434 patients from 7 hospitals in Castilla La Mancha were enrolled into the study from 2001 to 2015. Results Seventy-seven percent of patients were female, with a mean age at diagnosis of 48 years. Papillary thyroid carcinoma accounted for 93% of cases. Mean tumor size was significantly smaller at final follow-up ( p < 0.05). Radioiodine ablation (RA) was performed in 84% of patients, and its use decreased during the study, especially in tumors with low recurrence risk. Recurrence occurred in 22% of patients and was associated to male gender, greater tumor size, multifocality, lymph node metastases, extrathyroid involvement, distant metastases and increasing thyroglobulin antibody titers. At the end of follow-up 76.2% of patients were alive and free of disease, 2.4% had died from DTC. Overall survival of the cohort was 95.1% at 15 years of follow-up. Conclusions Characteristics of DTC in this Spanish cohort are similar to those reported in other studies in our country. Final results were excellent and use of treatment (RA) was consistent with risk-stratified recommendations.