The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial

• Published in: Endocrinología, diabetes y nutrición. diabetes y nutrición., 2019-12, Vol.66 (10), p.647-653
• Main Authors: Mohsenpour, Mohammad Ali, Kaseb, Fatemeh, Nazemian, Reza, Mozaffari-Khosravi, Hassan, Fallahzadeh, Hossein, Salehi-Abargouei, Amin
• Format: Article
• Language: English
• Subjects: Alcoholes de azúcar; Azúcares; Blood glucose control; Control de la glucemia; Diabetes; Edulcorante; Sugar alcohols; Sugars; Sweetener
• ISSN: 2530-0180; 2530-0180
• DOI: 10.1016/j.endien.2019.11.001

Several sweeteners are introduced to replace sucrose in the human diet. However, they had their own limitations and concerns, particularly in terms of their taste and their long-term health consequences. This study examined the effect of a new mixture of sugars and sugar alcohol on the postprandial blood glucose levels and its possible gastrointestinal (GI) adverse reactions in human adults. In this double-blind three-way randomized clinical trial, adults (21 with type 2 diabetes and 20 healthy) received 300ml of three beverages containing 50g glucose, sucrose, and lacritose (a mixture of lactose, fructose, sucrose, and erythritol) when they were in the fasted state in a random order. Postprandial serum glucose was checked every 30min up to 2h and the gastrointestinal reactions were collected. The mean serum glucose was significantly lower in all time points after ingestion of the lacritose for participants with type 2 diabetes compared to glucose and sucrose (P