Endocrine disruptors and obesity: Obesogens

Abstract Incidence and prevalence of overweight and obesity have greatly increased over the past three decades in almost all countries around the world. This phenomenon is not easily explained by lifestyle changes in populations with very different initial habits. This has led to consider the influe...

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Bibliographic Details
Published in:Endocrinologia y nutrición (English ed.) 2012-04, Vol.59 (4), p.261-267
Main Authors: García-Mayor, Ricardo V, Larrañaga Vidal, Alejandra, Docet Caamaño, Maria F, Lafuente Giménez, Anunciación
Format: Article
Language:English
Subjects:
Bisfenol A
Bisphenol A
Derivados orgánicos del estaño
DES
Disruptores endocrinos
Endocrine disruptors
Endocrinology & Metabolism
Ftalatos
Genistein
Ginesteína
Obesogens
Obesógenos
Organotins
Phthalates
Prevalence of obesity
Prevalencia de obesidad
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Summary:Abstract Incidence and prevalence of overweight and obesity have greatly increased over the past three decades in almost all countries around the world. This phenomenon is not easily explained by lifestyle changes in populations with very different initial habits. This has led to consider the influence of other factors, the so-called endocrine disruptors, and more specifically obesogens. This study reviewed the available evidence about polluting chemical substances which may potentially be obesogens in humans: DES, genistein, bisphenol A, organotins (TBT, TPT), and phthalates. The first three groups of substances mainly act upon estrogen receptors, while organotins and phthalates activate PPARγ. It was concluded that evidence exists of the obesogenic effect of these chemical substances in tissues and experimental animals, but few data are available in humans.
ISSN:2173-5093
2173-5093
DOI:10.1016/j.endoen.2012.05.001