Decreased lung function with mediation of blood parameters linked to e-waste lead and cadmium exposure in preschool children

• Published in: Environmental pollution (1987) 2017-11, Vol.230, p.838-848
• Main Authors: Zeng, Xiang, Xu, Xijin, Boezen, H. Marike, Vonk, Judith M., Wu, Weidong, Huo, Xia
• Format: Article
• Language: English
• Subjects: Cadmium; Cadmium - analysis; Cadmium - blood; Child, Preschool; E-waste; Electronic Waste - statistics & numerical data; Environmental Exposure - analysis; Environmental Exposure - statistics & numerical data; Environmental Pollutants - blood; Female; Hemoglobin; Humans; Lead; Lead - blood; Lung function; Male; Metals, Heavy; Preschool children; Recycling; Respiratory Function Tests; Respiratory Tract Diseases - epidemiology
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2017.07.014

Blood lead (Pb) and cadmium (Cd) levels have been associated with lower lung function in adults and smokers, but whether this also holds for children from electronic waste (e-waste) recycling areas is still unknown. To investigate the contribution of blood heavy metals and lung function levels, and the relationship among living area, the blood parameter levels, and the lung function levels, a total of 206 preschool children from Guiyu (exposed area), and Haojiang and Xiashan (reference areas) were recruited and required to undergo blood tests and lung function tests during the study period. Preschool children living in e-waste exposed areas were found to have a 1.37 μg/dL increase in blood Pb, 1.18 μg/L increase in blood Cd, and a 41.00 × 109/L increase in platelet counts, while having a 2.82 g/L decrease in hemoglobin, 92 mL decrease in FVC and 86 mL decrease in FEV1. Each unit of hemoglobin (1 g/L) decline was associated with 5 mL decrease in FVC and 4 mL decrease in FEV1. We conclude that children living in e-waste exposed area have higher levels of blood Pb, Cd and platelets, and lower levels of hemoglobin and lung function. Hemoglobin can be a good predictor for lung function levels. [Display omitted] •Higher levels of Pb and platelets in blood are found in preschool children in Guiyu.•Living in Guiyu is associated with lower levels of hemoglobin and lung function.•Hemoglobin can be a good predictor of lung funciton levels.•Blood parameters mediate the association between living area and lung function.