Urinary bisphenol analogues concentrations and biomarkers of oxidative DNA and RNA damage in Chinese school children in East China: A repeated measures study

• Published in: Environmental pollution (1987) 2019-11, Vol.254 (Pt A), p.112921, Article 112921
• Main Authors: Zhou, Ying, Yao, Yuan, Shao, Yijun, Qu, Weidong, Chen, Yue, Jiang, Qingwu
• Format: Article
• Language: English
• Subjects: Bisphenol analogues; BPA; BPS; China; Oxidative damage; School children
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2019.07.089

The associations between bisphenol analogues (BPs) exposure and oxidative damage was explored in this 3-year longitudinal study of 275 school children in East China. Nine BPs in first morning urine samples were measured to assess BPs exposure, and 8-hydroxydeoxyguanosine (8-OHdG) and 8-oxo-7,8-dihydroguanosine (8-OHG) were measured as biomarkers of oxidative DNA and RNA damage. Linear mixed model (LMM) was used for repeated measures analysis. School children were mainly exposed to BPA, BPS, BPF, and BPAF (detection frequencies: 97.9%, 42.2%, 13.3%, and 12.8%) with median concentrations of 1.55, 0.355, 0.236 and 0.238 μg g−1Cre, respectively. An interquartile range (IQR) increase in urinary BPA was significantly associated with 12.9% (95% CI: 6.1%, 19.6%) increase in 8-OHdG and 19.4% (95% CI: 11.7%, 27.1%) increase in 8-OHG, and for total of BPs (the sum of BPA, BPS, BPF, and BPAF), they were 17.4% (95% CI: 8.9%, 26.0%) for 8-OHdG and 25.9% (95% CI: 16.1%, 35.7%) for 8-OHG, respectively. BPS was positively associated with 8-OHG, but not with 8-OHdG. The study found positive associations of urinary levels of BPA and total BPs with 8-OHdG and 8-OHG and indicated that BPs exposure might cause oxidative RNA damage. [Display omitted] •Nine BPs and biomarkers of oxidative DNA and RNA damage were repeatedly measured in urine samples.•Chinese school children were mainly exposed to BPA, BPS, BPF, and BPAF in the longitudinal study.•Higher levels exposure of children to BPS was found in this study compared with the previous studies.•Elevated urinary levels of BPA and total BPs were positively associated with biomarkers of oxidative DNA and RNA damage.•Urinary BPS was significantly and positively related to oxidative RNA damage. Chinese school children were mainly exposed to BPA, BPS, BPF, and BPAF. In the longitudinal study, elevated urinary levels of BPA and total bisphenol analogues were positively associated with biomarkers of oxidative DNA and RNA damage.