The associations of particulate matter short-term exposure and serum lipids are modified by vitamin D status: A panel study of young healthy adults

Particulate matter (PM) exposure is associated to the adverse change in blood lipids. Vitamin D is beneficial to lipid metabolism, but whether vitamin D levels modifies the impact of air pollutants on lipids is unclear. The purpose of the study was to investigate if vitamin D modifies the associatio...

Full description

Saved in:
Bibliographic Details
Published in:Environmental pollution (1987) 2023-01, Vol.317, p.120686, Article 120686
Main Authors: Li, Jia-Min, Yang, Han-Yu, Wu, Si-Han, Dharmage, Shyamali C., Jalaludin, Bin, Knibbs, Luke D., Bloom, Michael S., Guo, Yuming, Morawska, Lidia, Heinrich, Joachim, Steve Hung Lam, Yim, Lin, Li-Zi, Zeng, Xiao-Wen, Yang, Bo-Yi, Chen, Gong-Bo, Liu, Ru-Qing, Dong, Guang-Hui, Hu, Li-Wen
Format: Article
Language:English
Subjects:
acute exposure
Adult
air
Air Pollutants - analysis
Air Pollution - analysis
Blood lipids
blood serum
China
Environmental Exposure
Humans
Interaction
lipid metabolism
Lipids
low density lipoprotein cholesterol
Particulate matter
Particulate Matter - analysis
particulates
people
pollution
Vitamin D
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Particulate matter (PM) exposure is associated to the adverse change in blood lipids. Vitamin D is beneficial to lipid metabolism, but whether vitamin D levels modifies the impact of air pollutants on lipids is unclear. The purpose of the study was to investigate if vitamin D modifies the associations of PM and serum lipids in young healthy people. From December 2017 to January 2018, a panel study with five once weekly follow-ups was conducted on 88 healthy adults aged 21.09 (1.08) (mean (SD)) years on average in Guangzhou, China. We measured serum lipids, serum 25-hydroxyvitamin D (25(OH)D) concentrations (440 blood samples in total), mass concentrations of particulate matter with diameters ≤2.5 μm (PM2.5), ≤1.0 μm (PM1.0), and ≤0.5 μm (PM0.5), and number concentrations of particulate matter with diameters ≤0.2 μm (PN0.2) and ≤0.1 μm (PN0.1) at each follow-up. Linear mixed-effect models were applied to assess the interaction of vitamin D and size-fractionated PM short-term exposure on four lipid metrics. We found the interactions between 25(OH)D and size-fractionated PM exposure on blood lipids in different lags (lag 3 days and 4 days). An interquartile range increase in PM2.5, PM1.0, PM0.5 were significantly associated with increments of 12.30%, 12.99%, and 13.66% in triglycerides (TGs) at lag 4 days at vitamin D levels
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2022.120686