Prenatal exposure to phthalates and polybrominated diphenyl ethers on neonatal health: A birth cohort study in Guangxi, China

• Published in: Environmental research 2023-01, Vol.216 (Pt 2), p.114571, Article 114571
• Main Authors: Qian, Bo, Zheng, Zhao-xuan, Yang, Lei, Wang, Cheng-qiang, Lin, Yu-Chun, Lin, Zhong-Ning
• Format: Article
• Language: English
• Subjects: Birth Cohort; Birth outcomes; China - epidemiology; Cohort Studies; Female; Halogenated Diphenyl Ethers - toxicity; Humans; Infant Health; Infant, Newborn; Male; Maternal Exposure - adverse effects; Neonatal disease; PAEs; PBDEs; Phthalic Acids - toxicity; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - epidemiology; Zhuang nationality
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2022.114571

Few epidemiological studies have focused on prenatal phthalates (PAEs) and polybrominated diphenyl ethers (PBDEs) exposure to neonatal health in China. This study aimed to assess the associations between prenatal PAEs and PBDEs exposure and neonatal health in Guangxi, a Zhuang autonomous region of China. Concentrations of 4 PAEs metabolites (mPAEs) and 5 PBDEs congeners were measured in the serum of 267 healthy pregnant women. Birth outcomes and clinical data of neonates were collected after delivery. Mono-(2-Ethylhexyl) phthalate (MEHP) (81.52%) and BDE47 (35.21%) were the mPAEs and PBDEs congeners with the highest detection rate in serum. Prenatal exposures to mono-n-butyl phthalate (MBP), MEHP, and ΣmPAEs were negatively associated with birth weight (BW), birth length (BL), and gestational age (GA). Higher exposures to MBP, MEHP, and ΣmPAEs were associated with an increased odds ratio (OR) for low birth weight (LBW), but exposure to BDE28 exhibited the opposite effect. Moreover, higher exposures to MBP, MEHP, ΣmPAEs, BDE99, and ΣPBDEswere associated with an increased OR for premature birth (PTB) (P