An efficient removal approach for degradation of metformin from aqueous solutions with sulfate radicals

• Published in: Environmental research 2023-01, Vol.217, p.114852, Article 114852
• Main Authors: Parra-Marfil, A., López-Ramón, M.V., Aguilar-Aguilar, A., García-Silva, I.A., Rosales-Mendoza, S., Romero-Cano, L.A., Bailón-García, E., Ocampo-Pérez, R.
• Format: Article
• Language: English
• Subjects: Degradation; Emerging pollutants; Indirect photolysis; Kinetics; Metformin; Oxidants; Oxidation-Reduction; SO4•- radicals; Sulfates - chemistry; Ultraviolet Rays; Wastewater treatment; Water; Water Pollutants, Chemical - analysis
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2022.114852

Metformin consumption for diabetes treatment is increasing, leading to its presence in wastewater treatment plants where conventional methods cannot remove it. Therefore, this work aims to analyze the performance of advanced oxidation processes using sulfate radicals in the degradation of metformin from water. Experiments were performed in a photoreactor provided with a low-pressure Hg lamp, using K2S2O8 as oxidant and varying the initial metformin concentration (CA0), oxidant concentration (Cox), temperature (T), and pH in a response surface experimental design. The degradation percentages ranged from 26.1 to 87.3%, while the mineralization percentages varied between 15.1 and 64%. Analysis of variance (ANOVA) showed that the output variables were more significantly affected by CA0, Cox, and T. Besides, a reduction of CA0 and an increase of Cox up to 5000 μM maximizes the metformin degradation since the generation of radicals and their interaction with metformin molecules are favored. For the greatest degradation percentage, the first order apparent rate constant achieved was 0.084 min−1. Furthermore, while in acidic pH, temperature benefits metformin degradation, an opposite behavior is obtained in a basic medium because of recombination and inhibition reactions. Moreover, three degradation pathways were suggested based on the six products detected by HPLC-MS: N-cyanoguanidine m/z = 85; N,N-dimethylurea m/z = 89; N,N-dimethyl-cyanamide m/z = 71 N,N-dimethyl-formamide m/z = 74; glicolonitrilo m/z = 58; and guanidine m/z = 60. Finally, it was shown that in general the toxicity of the degradation byproducts was lower than the toxicity of metformin toward Chlamydomonas reinhardtii.