Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero

Vigabatrin (VGB) is an important treatment option for infantile spasms. Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug. The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been...

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Bibliographic Details
Published in:Epilepsy research 2005-06, Vol.65 (1), p.117-120
Main Authors: Sorri, Iiris, Herrgård, Eila, Viinikainen, Katriina, Pääkkönen, Ari, Heinonen, Seppo, Kälviäinen, Reetta
Format: Article
Language:English
Subjects:
Adult
AED
Anticonvulsants - adverse effects
Biological and medical sciences
Child
Epilepsy - drug therapy
Female
Functional Laterality
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Neurologic Examination - methods
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Pregnancy
Prenatal Exposure Delayed Effects
Reaction Time - drug effects
Uterus - drug effects
Vigabatrin
Vigabatrin - adverse effects
Viral diseases
Viral diseases of the nervous system
Vision Disorders - etiology
Visual Acuity - drug effects
Visual fields
Visual Fields - drug effects
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Summary:Vigabatrin (VGB) is an important treatment option for infantile spasms. Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug. The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited. We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2005.04.001