Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures

The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the...

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Bibliographic Details
Published in:Epilepsy research 2005-07, Vol.65 (3), p.153-159
Main Authors: Noh, Hae Sook, Kang, Sang Soo, Kim, Dong Wook, Kim, Young Hee, Park, Chang Hwan, Han, Jae Yoon, Cho, Gyeong Jae, Choi, Wan Sung
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calbindin 1
Calbindins
Diseases of the nervous system
Food, Formulated
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus - drug effects
Hippocampus - metabolism
Immunohistochemistry - methods
Kainic Acid
Ketone Bodies - administration & dosage
Male
Medical sciences
Mice
Mice, Inbred ICR
Nervous system (semeiology, syndromes)
Neurology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
S100 Calcium Binding Protein G - metabolism
Seizures - chemically induced
Seizures - metabolism
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Summary:The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These results suggest that the neuroprotective effect of the KD on the KA-induced toxicity may be, in part, mediated via an increased expression of CB.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2005.05.008