Nitrate and nitrite concentrations in rabbit saliva

Abstract The purpose of this work was to investigate the interest of rabbits for studying pharmacology and toxicology of dietary nitrate. Twenty-one females were given 1, 300 and 600 mg/l nitrate in drinking water for 11 weeks. Saliva and blood were analysed for nitrate/nitrite. There is a linear re...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2007-01, Vol.23 (1), p.132-134
Main Authors: Djekoun-Bensoltane, S, Kammerer, M, Larhantec, M, Pilet, N, Thorin, C
Format: Article
Language:English
Subjects:
Drinking water
Emergency
Nitrate
Nitrite
Rabbit
Rat
Saliva
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Summary:Abstract The purpose of this work was to investigate the interest of rabbits for studying pharmacology and toxicology of dietary nitrate. Twenty-one females were given 1, 300 and 600 mg/l nitrate in drinking water for 11 weeks. Saliva and blood were analysed for nitrate/nitrite. There is a linear relationship between the amounts of nitrate ingested and amount of nitrate in saliva, contrary to what is observed in rats. However, salivary nitrite concentrations remain low, and nitrate reductase activity in the oral cavity of the rabbit seems very weak.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2006.07.007