Risperidone interacts with serum albumin forming complex

Highlights ► Interaction of risperidone to albumin was studied by fluorescence quenching technique. ► Risperidone forms complex with serum albumins. ► The primary binding site for risperidone in albumin could be located in sub domain IB.

Saved in:
Bibliographic Details
Published in:Environmental toxicology and pharmacology 2012-03, Vol.33 (2), p.262-266
Main Authors: Fragoso, Viviane Muniz, Silva, Dilson, Cruz, Frederico Alan de Oliveira, Cortez, Célia Martins
Format: Article
Language:English
Subjects:
Albumin
Animals
Antipsychotic Agents - chemistry
Antipsychotic Agents - metabolism
Antipsychotic drug
Binding Sites
Cattle
Emergency
Fluorescence quenching
Humans
Protein Binding
Protein Structure, Tertiary
Risperidone
Risperidone - chemistry
Risperidone - metabolism
Serum Albumin - chemistry
Serum Albumin - metabolism
Serum Albumin, Bovine - metabolism
Spectrometry, Fluorescence
Tryptophan
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Interaction of risperidone to albumin was studied by fluorescence quenching technique. ► Risperidone forms complex with serum albumins. ► The primary binding site for risperidone in albumin could be located in sub domain IB.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2011.11.007