The relationship among IL-13 , GSTP1 , and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico

Highlights ► We genotyped a population of asthmatic and non-asthmatic children from Northern Mexico. ► Three genes were analyzed: IL13 (−1112 C > T and Arg110Gln), GSTP1 (Ile105Val) and CYP1A1 (Ile462Val) and exposure to environmental tobacco smoke was assessed, as well. ► Polymorphisms studied h...

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Published in:Environmental toxicology and pharmacology 2012-03, Vol.33 (2), p.226-232
Main Authors: Muñoz, Balam, Magaña, Jonathan J, Romero-Toledo, Israel, Juárez-Pérez, Evelyn, López-Moya, Andrea, Leyva-García, Norberto, López-Campos, Celsa, Dávila-Borja, Víctor M, Albores, Arnulfo
Format: Article
Language:English
Subjects:
Age Factors
Asthma
Asthma - enzymology
Asthma - genetics
Asthma - immunology
Case-Control Studies
Chi-Square Distribution
Child
CYP1A1
Cytochrome P-450 CYP1A1 - genetics
Emergency
Environmental Tobacco smoke
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Glutathione S-Transferase pi - genetics
GSTP1
Humans
IL-13
Interleukin-13 - genetics
Logistic Models
Male
Mexico
Multivariate Analysis
Odds Ratio
Polymorphism
Polymorphism, Genetic
Risk Assessment
Risk Factors
Tobacco Smoke Pollution - adverse effects
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Summary:Highlights ► We genotyped a population of asthmatic and non-asthmatic children from Northern Mexico. ► Three genes were analyzed: IL13 (−1112 C > T and Arg110Gln), GSTP1 (Ile105Val) and CYP1A1 (Ile462Val) and exposure to environmental tobacco smoke was assessed, as well. ► Polymorphisms studied here were not useful markers for predicting bronchial asthma. ► Further studies including larger samples, clinical assessments, and individuals from different regions are required.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2011.12.007