Enhanced effects by mixtures of three estrogenic compounds at environmentally relevant levels on development of Chinese rare minnow ( Gobiocypris rarus )

• Published in: Environmental toxicology and pharmacology 2012-03, Vol.33 (2), p.277-283
• Main Authors: Jin, Shiwei, Yang, Fangxing, Liao, Tao, Hui, Yang, Wen, Sheng, Xu, Ying
• Format: Article
• Language: English
• Subjects: 17β-Estradiol; Animals; Chinese rare minnow; Combined effects; Cyprinidae - embryology; Cyprinidae - growth & development; Cyprinidae - metabolism; Diethylstilbestrol; Diethylstilbestrol - toxicity; Dose-Response Relationship, Drug; Drug Synergism; Embryo, Nonmammalian - drug effects; Embryo, Nonmammalian - metabolism; Emergency; Endocrine Disruptors - metabolism; Endocrine Disruptors - toxicity; Estradiol - toxicity; Estrogens - metabolism; Estrogens - toxicity; Female; Fish Proteins - metabolism; Larva - drug effects; Larva - metabolism; Male; Nonylphenol; Phenols - toxicity; Risk Assessment; Sex Ratio; Sexual Development - drug effects; Testis - drug effects; Testis - growth & development; Time Factors; Vitellogenin; Vitellogenins - metabolism; Water Pollutants, Chemical - metabolism; Water Pollutants, Chemical - toxicity
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2011.12.016

Highlights ► Vitellogenin induction was observed at the low exposed concentration. ► Significant reduction of testis somatical index (TSI) was detected in adult males. ► The sex ratio of adult fish skewed to female was found at high concentration of the mixture. ► Co-exposure of xenoestrgens can enhance the adverse effects on the development of fish. ► Adverse effects can be induced by co-exposure of low concentration xenoestrgens.