Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats

Highlights ► The roots of Trichosanthes dioica are traditionally used for medicinal purposes in India. ► The protective effect of T. dioica root extract (TDA) against arsenic induced toxicity in albino rats was evaluated. ► TDA was treated orally to rats for 20 days prior to arsenic intoxication for...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2012-05, Vol.33 (3), p.394-402
Main Authors: Bhattacharya, Sanjib, Haldar, Pallab Kanti
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Antioxidants - therapeutic use
Arsenic Poisoning - drug therapy
Arsenic Poisoning - metabolism
Arsenic toxicity
DNA Fragmentation - drug effects
Emergency
Glutathione - metabolism
Glutathione Transferase - metabolism
Kidney - drug effects
Kidney - growth & development
Kidney - metabolism
Liver - drug effects
Liver - growth & development
Liver - metabolism
Male
Organ Size - drug effects
Oxidative stress
Oxidative Stress - drug effects
Oxidoreductases - metabolism
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Rats
Rats, Wistar
Root
Sodium arsenite
Thiobarbituric Acid Reactive Substances - metabolism
Trichosanthes
Trichosanthes dioica
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Summary:Highlights ► The roots of Trichosanthes dioica are traditionally used for medicinal purposes in India. ► The protective effect of T. dioica root extract (TDA) against arsenic induced toxicity in albino rats was evaluated. ► TDA was treated orally to rats for 20 days prior to arsenic intoxication for 8 days. ► Then different hematological, serum, hepatic and renal parameters were evaluated. ► Results revealed marked ameliorative effect of TDA in arsenic treated rats by alleviation of oxidative stress.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.02.003