DNA polymerase beta is involved in the protection against the cytotoxicity and genotoxicity of cigarette smoke

Highlights ▸ polβ−/− , polβ+/+ and polβoe cells were first used to evaluate the toxicity of CSE. ▸ The toxicity of cigarette smoke should be due to ROS-mediated DNA damage. ▸ polβ involves in protection against cytotoxicity and genotoxicity of cigarette smoke.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2012-09, Vol.34 (2), p.370-380
Main Authors: Cui, Jie, Zhao, Wei, Xu, Xin, Yang, Mo, Ren, Yaou, Zhang, Zunzhen
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cell Survival - drug effects
Comet Assay
Complex Mixtures - toxicity
Cytotoxins - toxicity
DNA Damage
DNA Polymerase beta - genetics
DNA Polymerase beta - metabolism
DNA Repair
Embryo, Mammalian
Emergency
Fibroblasts - drug effects
Fibroblasts - metabolism
Mice
Micronucleus Tests
Mutagens - toxicity
Nicotiana
Reactive Oxygen Species - metabolism
Smoke
Smoking - adverse effects
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Description
Summary:Highlights ▸ polβ−/− , polβ+/+ and polβoe cells were first used to evaluate the toxicity of CSE. ▸ The toxicity of cigarette smoke should be due to ROS-mediated DNA damage. ▸ polβ involves in protection against cytotoxicity and genotoxicity of cigarette smoke.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.05.012