Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells

Highlights ► Inhibitory effect of fucoxanthin on the proliferation of melanoma cell lines (B16F10 cells). ► The G0 / G1 phase cell cycle arrest and apoptosis were induced by fucoxanthin. ► Cell cycle arrest in G0 / G1 phase was associated with upregulating the level of p16INK4A and p27Kip1 . ► Fucox...

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Published in:Environmental toxicology and pharmacology 2013-01, Vol.35 (1), p.39-46
Main Authors: Kim, Kil-Nam, Ahn, Ginnae, Heo, Soo-Jin, Kang, Sung-Myung, Kang, Min-Cheol, Yang, Hye-Mi, Kim, Daekyung, Roh, Seong Woon, Kim, Se-Kwon, Jeon, Byong-Tae, Park, Pyo-Jam, Jung, Won-Kyo, Jeon, You-Jin
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Bcl-xL
Cell arrest
Cell Cycle - drug effects
Cell Cycle Proteins - metabolism
Cell Line, Tumor
Cell Proliferation - drug effects
Emergency
Fucoxanthin
Melanoma cell lines (B16F10 cells)
Melanoma, Experimental - drug therapy
Melanoma, Experimental - metabolism
Melanoma, Experimental - pathology
Mice
Mice, Inbred BALB C
p27Kip1
Tumor Burden - drug effects
Xanthophylls - pharmacology
Xanthophylls - therapeutic use
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Summary:Highlights ► Inhibitory effect of fucoxanthin on the proliferation of melanoma cell lines (B16F10 cells). ► The G0 / G1 phase cell cycle arrest and apoptosis were induced by fucoxanthin. ► Cell cycle arrest in G0 / G1 phase was associated with upregulating the level of p16INK4A and p27Kip1 . ► Fucoxanthin induced apoptosis by inhibition of Bcl-xL. ► Fucoxanthin suppressed in vivo growth of melanoma in Balb/c mice.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.10.002