Genotoxic effects of 8-hydroxylquinoline in loach ( Misgurnus anguillicaudatus ) assessed by the micronucleus test, comet assay and RAPD analysis

Highlights ► Acute toxicity test indicated that 8-hydroxylquinoline (8-HOQ) had obvious toxicity effect on loach. ► The genetic toxicity effects of 8-HOQ on loach were obvious dose–effect and time–effect relationships. ► The sequences and patterns of changes RAPD bands showed that 8-HOQ could induce...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2013-05, Vol.35 (3), p.434-443
Main Authors: Nan, Ping, Xia, Xiao-hua, Du, Qi-yan, Chen, Jian-jun, Wu, Xiao-hua, Chang, Zhong-jie
Format: Article
Language:English
Subjects:
8-Hydroxylquinoline
Animals
Comet Assay
Cypriniformes
DNA Damage
Emergency
Genotoxicity
Lethal Dose 50
Loach (Misgurnus anguillicaudatus)
Micronuclei, Chromosome-Defective
Micronucleus
Micronucleus Tests
Mutagens - toxicity
Oxyquinoline - toxicity
Pesticides - toxicity
Random Amplified Polymorphic DNA Technique
RAPD
Water Pollutants, Chemical - toxicity
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Summary:Highlights ► Acute toxicity test indicated that 8-hydroxylquinoline (8-HOQ) had obvious toxicity effect on loach. ► The genetic toxicity effects of 8-HOQ on loach were obvious dose–effect and time–effect relationships. ► The sequences and patterns of changes RAPD bands showed that 8-HOQ could induce DNA damage in loach. ► Our research proposed that the comet assay and RAPD assay applied to fish as a biomonitoring methodology to evaluate 8-HOQ genotoxicity on organisms.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.02.005