Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity

The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats. Myocardial injury was induced by subcutaneous injection of isoproterenol hydrochloride (85mg/kg BW) twice at an interval of 24h, for two consecutive days. HDN...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2012-07, Vol.64 (5), p.449-452
Main Authors: Selvaraj, Palanisamy, Pugalendi, Kodukkur Viswanathan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Cardiotonic Agents - toxicity
cholesterol
Disease Models, Animal
free fatty acids
Heart
Heart - drug effects
Hesperidin
Hesperidin - pharmacology
Investigative techniques, diagnostic techniques (general aspects)
Isoproterenol
Isoproterenol - toxicity
Lipid Metabolism - drug effects
Lipids - analysis
Lipids - blood
Lipoproteins
liver
Liver - drug effects
Male
Medical sciences
Myocardial injury
Myocardial Ischemia - chemically induced
Myocardial Ischemia - metabolism
Myocarditis. Cardiomyopathies
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
phospholipids
Plasma lipids
Rats
Rats, Wistar
subcutaneous injection
Tissue lipids
tissues
triacylglycerols
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Summary:The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats. Myocardial injury was induced by subcutaneous injection of isoproterenol hydrochloride (85mg/kg BW) twice at an interval of 24h, for two consecutive days. HDN was administered by post-orally at a dose of 200mg/kg BW. The results showed increased levels of plasma cholesterol, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) and decreased level of high density lipoprotein-cholesterol (HDL-C) in ISO-induced rats. ISO rats also showed an increase in cholesterol, TG and FFA and decrease in PL levels in the heart and liver tissues. HDN treatment brought the above parameters towards normal level. This experiment shows that HDN possesses hypolipidemic effect in ISO-induced rats.
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2010.10.012