Reproductive toxicity of Roundup herbicide exposure in male albino rat

The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rat...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2017-09, Vol.69 (7), p.461-468
Main Authors: Owagboriaye, Folarin O., Dedeke, Gabriel A., Ademolu, Kehinde O., Olujimi, Olarenwaju O., Ashidi, Joseph S., Adeyinka, Aladesida A.
Format: Article
Language:English
Subjects:
Agriculture
Animals
Fertility - drug effects
Food poison
Glycine - analogs & derivatives
Glycine - toxicity
Glyphosate
Herbicide
Herbicides - toxicity
Male
Random Allocation
Rats
Reproduction
Reproduction - drug effects
Roundup
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Summary:The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rats per group orally exposed to Roundup at 3.6mg/kg body weight(bw), 50.4mg/kgbw and 248.4mg/kgbw of glyphosate concentrations for 12 weeks while the control group was given distilled water. Serum level of reproductive hormone (testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin), oxidative stress indices in the testicular tissue, epididymal sperm morphology assessment and testicular histopathology of the rats were used as a diagnostic marker of reproductive dysfunction. Significant (p
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2017.04.007