Antihyperglycaemic, antihyperlipidaemic and β cell regenerative effects of Spondias pinnata (Linn. f.) Kurz. bark extract on streptozotocin induced diabetic rats

In Sri Lanka, Spondias pinnata (Linn. f.) Kurz (Family: Anacardiaceae) is popular in traditional Ayurvedic medicine for the treatment of diabetes mellitus. This study investigated the effect of aqueous bark extract of S. pinnata on antihyperglycaemic, antihyperlipidaemic activities and β-cell regene...

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Published in:European journal of integrative medicine 2014-10, Vol.6 (5), p.588-596
Main Authors: Attanayake, Anoja Priyadarshani, Jayatilaka, Kamani Ayoma Perera Wijewardana, Pathirana, Chitra, Mudduwa, Lakmini Kumari Boralugoda
Format: Article
Language:English
Subjects:
Antihyperglycaemic activity
Diabetes
Immunohistochemistry
Spondias pinnata
β-Cell regeneration
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Summary:In Sri Lanka, Spondias pinnata (Linn. f.) Kurz (Family: Anacardiaceae) is popular in traditional Ayurvedic medicine for the treatment of diabetes mellitus. This study investigated the effect of aqueous bark extract of S. pinnata on antihyperglycaemic, antihyperlipidaemic activities and β-cell regenerative potential in streptozotocin induced diabetic rats. Dose, long term effects and acute toxicity were also investigated. A series of experimental studies were conducted using S. pinnata. Diabetes was induced in rats by injecting them with streptozotocin (65mg/kg, ip). Control rats were either healthy untreated, or diabetes induced untreated rats which only received distilled water. Diabetic rats were treated with different dose to identify the optimum effective dose of S. pinnata. having identified the optimum dose (1.00g/kg) and glibenclamide (0.50mg/kg) was given daily for 30 days. The assessment of biochemical parameters, histopathology and immunohistochemistry of the pancreas occurred at 30 days. The percentage of glycosylated hemoglobin decreased together with a concomitant increase in the concentration of serum insulin and C-peptide in S. pinnata treated diabetic rats (p
ISSN:1876-3820
1876-3839
DOI:10.1016/j.eujim.2014.03.010