Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differenc...

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Published in:European neuropsychopharmacology 2006-02, Vol.16 (2), p.123-128
Main Authors: Choi, Ihn-Geun, Kee, Baik Seok, Son, Hyun-Gyun, Ham, Byung Joo, Yang, Byung-Hwan, Kim, Seok Hyeon, Lee, Jun-Suk, Son, Bong Ki, Lee, Byeong-Yong, Lee, Sang-Yeol, Chai, Young-Gyu, Shin, Hyoung Doo
Format: Article
Language:English
Subjects:
Adult
Alcohol Dehydrogenase - genetics
Alcohol dehydrogenase 2
Alcoholism
Alcoholism - enzymology
Alcoholism - genetics
Alcoholism - metabolism
Aldehyde Dehydrogenase - genetics
Aldehyde dehydrogenase 2
Alleles
DNA - genetics
Dopamine Plasma Membrane Transport Proteins - genetics
Dopamine transporter
Family
Family history
Gene Frequency
Genotype
Humans
Isoenzymes - genetics
Korea - epidemiology
Male
Polymorphism, Genetic - genetics
Reverse Transcriptase Polymerase Chain Reaction
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin transporter
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Summary:One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2005.07.006