New Trends in Bladder Cancer Management

• Published in: European urology supplements : official journal of the European Association of Urology 2007-03, Vol.6 (4), p.388-395
• Main Authors: Irani, Jacques, Mottet, Nicolas, Ribal Caparrós, María Jose, Teillac, Pierre
• Format: Article
• Language: English
• Subjects: Bacillus Calmette-Guérin; Bladder cancer; EORTC tables; Hospital volume; Interferon-α; Invasive; Mitomycin; Quality of life; Superficial; Time to cystectomy; Upper urinary tract tumours; Urology
• ISSN: 1569-9056; 1878-1500
• DOI: 10.1016/j.eursup.2006.12.010

Abstract Objectives This paper describes and discusses the most relevant new findings on bladder cancer (BCa) that were presented at the 2006 annual meetings from the European Association of Urology (EAU), American Urological Association (AUA) and the American Society of Clinical Oncology (ASCO). Methods The most relevant abstracts on BCa were selected by experts in the field of BCa and discussed during a closed meeting. Results The most relevant new data on BCa came from the EAU and AUA meetings. Major topic of the meetings was the development of the EORTC prognostic tables to calculate short- and long-term recurrence and progression rates of patients with superficial BCa. Many (controversial) studies discussed the diagnostic and prognostic potentials of the biomarkers survivin and NMP22. Two studies involved the treatment of patients with refractory superficial BCa. Intravesical therapy with Bacillus Calmette-Guérin + interferon-α was considered a promising therapy for patients who failed BCG therapy. With respect to invasive BCa, there were some controversial reports on the impact of delayed cystectomy or hospital volumes on (cancer-free) survival rates. The bladder cancer index was presented as a promising questionnaire to assess quality of life in patients with localised BCa. Finally, one study showed that extensive tumour necrosis in upper urinary tract tumours is a prognostic factor for poor patient outcome. Conclusions There were many interesting studies about BCa at this year's urologic meetings. Major headline was the introduction of the EORTC prognostic tables, which will probably lead to a major improvement in the evaluation and surveillance of patients with superficial BCa.