Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

• Published in: Experimental parasitology 2018-11, Vol.194, p.67-78
• Main Authors: Nor Azman, Nadiah Syafiqah, Hossan, Md Shahadat, Nissapatorn, Veeranoot, Uthaipibull, Chairat, Prommana, Parichat, Jin, Khoo Teng, Rahmatullah, Mohammed, Mahboob, Tooba, Raju, Chandramathi Samudi, Jindal, Hassan Mahmood, Hazra, Banasri, Mohd Abd Razak, Mohd Ridzuan, Prajapati, Vijay Kumar, Pandey, Rajan Kumar, Aminudin, Norhaniza, Shaari, Khozirah, Ismail, Nor Hadiani, Butler, Mark S., Zarubaev, Vladimir V., Wiart, Christophe
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - pharmacology; Anti-Infective Agents - toxicity; Antibacterial; Antileishmanial; Antimalarial; Antiviral; Apocynaceae - chemistry; Cell Line; Drug Synergism; Enterovirus B, Human - drug effects; Ethnopharmacology - methods; Furans - chemistry; Furans - isolation & purification; Furans - pharmacology; Furans - toxicity; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Influenza A Virus, H1N1 Subtype - drug effects; Inhibitory Concentration 50; Leishmania donovani - drug effects; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Lignans - toxicity; Malaysia; Medicinal plants; Medicine, East Asian Traditional - methods; Natural products; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - toxicity; Plants, Medicinal - chemistry; Plasmodium falciparum - drug effects; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Sesquiterpenes - toxicity; Tabernaemontana - chemistry; Uvaria - chemistry
• ISSN: 0014-4894; 1090-2449
• DOI: 10.1016/j.exppara.2018.09.020

Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against MRC-5 cells and Leishmania donovani by MTT, and chloroquine-resistant Plasmodium falciparum K1 strain by Histidine-Rich Protein II ELISA assays. None of the extract tested was cytotoxic to MRC-5 cells. Extracts of Uvaria grandiflora, Chilocarpus costatus, Tabernaemontana peduncularis, and Leuconotis eugenifolius had good activities against L. donovani with IC50