In vitro potential effect of Pipper longum methanolic extract against protoscolices of hydatid cysts

This study aimed to evaluate the efficacy of methanolic extract of P. longum (PLM) against protoscolices of hydatid cyst in vitro. Four different concentrations of PLM extract (25, 50, 100 and 150 mg/ml) were used for the experiments. The metabolites in the PLM extract were characterized by Gas chro...

Full description

Saved in:
Bibliographic Details
Published in:Experimental parasitology 2021-02, Vol.221, p.108051, Article 108051
Main Authors: Cheraghipour, Kourosh, Beiranvand, Marjan, Zivdari, Masoomeh, Amiri, Sana, Masoori, Leila, Nourmohammadi, Morteza, Maken Ali, Ali Safar, Abbaszadeh, Saber, Moradpour, Kobra, Marzban, Abdolrazagh
Format: Article
Language:English
Subjects:
Alkaloids - analysis
Animals
Echinococcosis - drug therapy
Echinococcosis - parasitology
Echinococcus granulosus
Echinococcus granulosus - drug effects
Flavonoids - analysis
Fruit - chemistry
Gas Chromatography-Mass Spectrometry
Glycosides - analysis
Goats
Hydatid cyst
Inhibitory Concentration 50
Liver - parasitology
Methanoilc extract
Microscopy, Electron, Scanning
Piper - chemistry
Pipper longum
Plant Extracts - analysis
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Saponins - analysis
Sheep
Tannins - analysis
Terpenes - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to evaluate the efficacy of methanolic extract of P. longum (PLM) against protoscolices of hydatid cyst in vitro. Four different concentrations of PLM extract (25, 50, 100 and 150 mg/ml) were used for the experiments. The metabolites in the PLM extract were characterized by Gas chromatography-mass spectrometry (GC-MS). The results showed the highest lethality of PLM extract in 50 mg/ml for 60 min exposure. The IC50 value obtained about 20 mg/ml for 60 min of PLM extract exposure. In this study, valuable findings were obtained for the first time about the scolicidal activity of P. longum, which is expected to conduct further studies in this field in the future. [Display omitted] •Methanoilc extract of Pipper longum was studied as an anti-hydatid cyst.•Pipper longum metabolites disrupted ultrastructure of hydatid cyst.•Abundant metabolites included piperine and Pyrrolidine derivatives.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2020.108051