Patient preference after switching guselkumab from prefilled syringe to an autoinjection pen in psoriasis and psoriatic arthritis patients

• Published in: Farmacia hospitalaria 2024-07
• Main Authors: Borrás-Blasco, Joaquin, García, Rebeca Alcalá, Cornejo-Uixeda, Silvia, Matellanes-Palacios, Maria, Casterá-Melchor, Elvira
• Format: Article
• Language: English
• Subjects: Artritis psoriasica; experiencia paciente; Guselkumab; Jeringa precargada; One-Press autoinjector pen; Patient experience; pluma One-Press; Prefilled syringe; Psoriasis; Psoriatic arthritis
• ISSN: 1130-6343
• DOI: 10.1016/j.farma.2024.07.002

We assessed pain, acceptability, patient preference, and tolerability of patients with psoriasis and psoriatic arthritis after switching guselkumab from a prefilled syringe to One-Press autoinjector pen. Patients with psoriasis and psoriatic arthritis treated for at least 6 months with guselkumab syringe were recruited from Jan 2019 to Dec 2022. Gender, age, diagnosis, self-administration, and pain perception of guselkumab prefilled syringe were recorded. At the first visit, patients completed a post-auto-injection syringe questionnaire before starting auto-injection pen administration. After 2 and 6 months of guselkumab self-injection using the One-Press autoinjector pen, patient experience, adherence, preference, pain, and safety of each administration were assessed using post-guselkumab by One-Press autoinjector pen questionnaire. 40 patients [psoriasis n=34, psoriatic arthritis n=6] were included. All patients self-administered guselkumab by One-Press autoinjector pen. Pain at the injection site was significantly reduced with the use of the One-Press autoinjector pen. All patients considered that using One-Press autoinjector pen was easier than the syringe, 98% chose the pen as their preferred delivery system. The One-Press autoinjector pen for guselkumab administration is presented as a preferred option, with a high satisfaction and less painful compared to the administration of guselkumab in a prefilled syringe. Evaluamos el dolor, satisfacción, preferencia y tolerabilidad de los pacientes con psoriasis y artritis psoriásica tras cambiar guselkumab de jeringa precargada a pluma autoinyectora One-Press. Se incluyeron pacientes con psoriasis y artritis psoriásica tratados durante al menos 6 meses con la jeringa de guselkumab entre enero-2019 y diciembre-2022. Se registraron sexo, edad, diagnóstico, autoadministración y percepción del dolor de la jeringa precargada previo al uso de la pluma autoinyectora. Tras 2 y 6 meses de utilizando la pluma autoinyectora One-Press, se evaluó la experiencia, la adherencia, preferencia, dolor y seguridad de la pluma mediante cuestionario. Se incluyeron 40 pacientes [psoriasis n = 34, artritis psoriásica n = 6]. Todos los pacientes se autoadministraron guselkumab usando la pluma autoinyectora One-Press. El dolor en el lugar de la inyección se redujo significativamente con el uso de la pluma autoinyectora One-Press. Todos los pacientes consideraron que el uso de la pluma autoinyectora One-Press era más fácil que la jeri