Effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures in locally corticosteroid-induced Achilles tendinosis: An experimental study on rats

Abstract Background To determine the effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures, 72 tendons of 36 Wistar rats were injected with betamethasone sodium phosphate. Methods By the end of fourth week, both tendons were tenotomized and repaired, then the samp...

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Bibliographic Details
Published in:Foot and ankle surgery 2009, Vol.15 (1), p.22-27
Main Authors: Çoban, İbrahim, M.D, Satoğlu, İsmail Safa, M.D, Gültekin, Alper, M.D, Tuna, Burçin, M.D, Tatari, Hasan, M.D, Fidan, Mustafa, Ph.D
Format: Article
Language:English
Subjects:
Achilles tendinosis
Achilles Tendon - injuries
Achilles tendon rupture
Amnion
Amniotic Fluid
Animals
Betamethasone - administration & dosage
Betamethasone - analogs & derivatives
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Combined Modality Therapy
Diseases of the osteoarticular system
Glucocorticoids - administration & dosage
Human amniotic fluid
Human amniotic membrane
Humans
Injuries of the limb. Injuries of the spine
Male
Medical sciences
Orthopedics
Pharmacology. Drug treatments
Rats
Rats, Wistar
Rupture - therapy
Tendinopathy - chemically induced
Tendinopathy - complications
Traumas. Diseases due to physical agents
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Summary:Abstract Background To determine the effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures, 72 tendons of 36 Wistar rats were injected with betamethasone sodium phosphate. Methods By the end of fourth week, both tendons were tenotomized and repaired, then the samples were divided into three groups. The first group was left untreated after suturing. Human amniotic fluid was injected to the second and amniotic fluid and membrane were both administered to the third group. Twenty-four tendons were scored at the end of the first week, and 24 at the end of the second week histopathologically, and 24 biomechanically at the end of the third week. Results There was a significant statistical difference only between the histopathological results of Groups 2 and 3 at the first week. Conclusions Human amniotic membrane and fluid do not add anything to the healing process of Achilles tendon ruptures in the early phase.
ISSN:1268-7731
1460-9584
DOI:10.1016/j.fas.2008.06.005