Three lactic acid bacteria with anti-obesity properties: In vitro screening and probiotic assessment

The worldwide obesity epidemic has imposed human being a huge burden and attention had been drawn to manipulating the lactic acid bacteria (LAB) to improve obesity symptoms. In this study, a more comprehensive and reliable in vitro method was established to screen LAB with greater potential against...

Full description

Saved in:
Bibliographic Details
Published in:Food bioscience 2022-06, Vol.47, p.101724, Article 101724
Main Authors: Wei, Benliang, Peng, Zhen, Xiao, Muyan, Huang, Tao, Zheng, Wendi, Xie, Mingyong, Xiong, Tao
Format: Article
Language:English
Subjects:
Anti-obesity properties
Lactic acid bacteria
Principal component analysis
Probiotic properties
Strain
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The worldwide obesity epidemic has imposed human being a huge burden and attention had been drawn to manipulating the lactic acid bacteria (LAB) to improve obesity symptoms. In this study, a more comprehensive and reliable in vitro method was established to screen LAB with greater potential against obesity. Firstly, twenty-eight human feces-derived LAB strains were selected by assessing bile salt-acid tolerance and cholesterol lowering capacity. Subsequently, the triglyceride lowering capacity, bile salt hydrolase (BSH) activity, α-glucosidase activity inhibition capacity and Enterobacter cloacae (E. cloacae) growth inhibition capacity were tested for further evaluating the anti-obesity properties of LAB strains. Principal component analysis (PCA) of these results indicated that Limosilactobacillus reuteri (L. reuteri) NCUH003, Lactiplantibacillus plantarum (L. plantarum) NCUH046 and Limosilactobacillus fermentum (L. fermentum) NCUH068 exhibited favorable anti-obesity properties. Besides, the LAB displayed good gastrointestinal adaptability and antioxidant activity but no hemolytic activity, and they were sensitive to various antibiotics. These results indicated that L. reuteri NCUH003, L. plantarum NCUH046 and L. fermentum NCUH068 are potential for application in obesity treatment. [Display omitted] •A more comprehensive screening method in vitro for anti-obesity LAB was established.•Anti-obesity effects of LAB included lipid lowering, stronger BSH activity, enzymes activity and E. cloacae inhibition.•L. reuteri NCUH003, L. plantarum NCUH046 and L. fermentum NCUH068 were selected by principal component analysis.•The probiotic properties, antioxidant activity and safety of the selected LAB were evaluated.
ISSN:2212-4292
2212-4306
DOI:10.1016/j.fbio.2022.101724