Differential effects of oilseed protein hydrolysates in attenuating inflammation in murine macrophages

Proteins from underutilized defatted oilseed meals have been proposed as promising sources of bioactive peptides. This study was conducted to determine the anti-inflammatory activities of five oilseed proteins (flaxseed, rapeseed, sunflower, sesame and soybean) hydrolysed via alcalase, pepsin (at pH...

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Bibliographic Details
Published in:Food bioscience 2022-10, Vol.49, p.101860, Article 101860
Main Authors: Han, Ruixian, Hernández Álvarez, Alan J., Maycock, Joanne, Murray, Brent S., Boesch, Christine
Format: Article
Language:English
Subjects:
Anti-inflammatory properties
Bioactive peptide
Inflammation
LPS binding
Oilseeds
Protein hydrolysate
Ultrafiltration
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Summary:Proteins from underutilized defatted oilseed meals have been proposed as promising sources of bioactive peptides. This study was conducted to determine the anti-inflammatory activities of five oilseed proteins (flaxseed, rapeseed, sunflower, sesame and soybean) hydrolysed via alcalase, pepsin (at pH 1.3 and pH 2.1), respectively, and to compare these against two dairy proteins (whey, casein). The potential of protein hydrolysates of three different molecular weight fractions (Mw > 10 kDa, 3–10 kDa, < 3 kDa) to modulate nuclear factor kappa B (NF-κB) signalling was screened via RAW-Blue™ reporter cells. Fractions with Mw 
ISSN:2212-4292
2212-4306
DOI:10.1016/j.fbio.2022.101860