LysM proteins in mammalian fungal pathogens

The LysM domain is a highly conserved carbohydrate-binding module that recognizes polysaccharides containing N-acetylglucosamine residues. LysM domains are found in a wide variety of extracellular proteins and receptors from viruses, bacteria, fungi, plants and animals. LysM proteins are also presen...

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Bibliographic Details
Published in:Fungal biology reviews 2022-06, Vol.40, p.114-122
Main Author: Oguiza, José A.
Format: Article
Language:English
Subjects:
Chitinase
Effector
Fungal virulence
Fungi
LysM
Mammalian pathogen
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Summary:The LysM domain is a highly conserved carbohydrate-binding module that recognizes polysaccharides containing N-acetylglucosamine residues. LysM domains are found in a wide variety of extracellular proteins and receptors from viruses, bacteria, fungi, plants and animals. LysM proteins are also present in many species of mammalian fungal pathogens, although a limited number of studies have focused on the expression and determination of their putative roles in the infection process. This review summarizes the current knowledge and recent studies on LysM proteins in the main morphological groups of fungal pathogens that cause infections in humans and other mammals. Recent advances towards understanding the biological functions of LysM proteins in infections of mammalian hosts and their use as potential targets in antifungal strategies are also discussed.
ISSN:1749-4613
1878-0253
DOI:10.1016/j.fbr.2022.02.001