Absence of toxic effects in F344/N rats and B6C3F1 mice following subchronic administration of chromium picolinate monohydrate

Chromium picolinate monohydrate (CPM) is a synthetic compound heavily marketed to consumers in the United States for use as a dietary supplement for muscle building and weight loss. The National Toxicology Program (NTP) tested the toxicity of this compound based on the potential for widespread consu...

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Bibliographic Details
Published in:Food and chemical toxicology 2005, Vol.43 (1), p.21-29
Main Authors: Rhodes, M.C, Hebert, C.D, Herbert, R.A, Morinello, E.J, Roycroft, J.H, Travlos, G.S, Abdo, K.M
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological and medical sciences
blood chemistry
Body Composition - drug effects
Body Weight - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
chromium
dietary supplements
dosage
dose response
Dose-Response Relationship, Drug
Eating - drug effects
ergogenic aids
Estrus - drug effects
experimental diets
feed intake
Female
females
hematology
histopathology
Iron Chelating Agents - pharmacokinetics
Iron Chelating Agents - pharmacology
Iron Chelating Agents - toxicity
Male
males
Medical sciences
Metals and various inorganic compounds
Mice
Mice, Inbred Strains
mortality
Organ Size - drug effects
Picolinic Acids - pharmacokinetics
Picolinic Acids - pharmacology
Picolinic Acids - toxicity
product safety
Random Allocation
Rats
Rats, Inbred F344
Spermatozoa - drug effects
Survival Analysis
synthetic products
Tissue Distribution
tissue weight
toxicity testing
Toxicity Tests, Chronic
Toxicology
weight control
weight control agent
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Summary:Chromium picolinate monohydrate (CPM) is a synthetic compound heavily marketed to consumers in the United States for use as a dietary supplement for muscle building and weight loss. The National Toxicology Program (NTP) tested the toxicity of this compound based on the potential for widespread consumer exposure and lack of information about its toxicity. Groups of 10 male and 10 female F344/N rats and B6C3F(1) mice were exposed to 0, 80, 240, 2000, 10,000, or 50,000 ppm CPM in feed for 13 weeks. CPM administration produced no effect on body weight gain or survival of rats or mice. Organ weights and organ/body weight ratios in exposed animals were generally unaffected by CPM. No compound-related changes in hematology and clinical chemistry parameters were observed. There were no histopathological lesions attributed to CPM in rats or mice.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2004.08.006