Protective role of phosphatidylcholine against cisplatin-induced renal toxicity and oxidative stress in rats

• Published in: Food and chemical toxicology 2013-08, Vol.58, p.388-393
• Main Authors: Lee, Ho Sung, Kim, Bum Keun, Nam, Yunsung, Sohn, Uy Dong, Park, Eon Sub, Hong, Soon Auck, Lee, Jong Hyuk, Chung, Yoon Hee, Jeong, Ji Hoon
• Format: Article
• Language: English
• Subjects: Acute renal failure; Animals; Antineoplastic Agents - toxicity; antioxidant activity; antioxidants; Biological and medical sciences; blood serum; catalase; Cisplatin; Cisplatin - toxicity; creatinine; enzyme activity; glutathione; glutathione peroxidase; hypertrophy; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Lipid Peroxidation; Male; Medical sciences; neoplasms; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; nephrotoxicity; Oxidative stress; Oxidative Stress - drug effects; Phosphatidylcholine; phosphatidylcholines; Phosphatidylcholines - pharmacology; protective effect; Rats; Rats, Wistar; reactive oxygen species; Renal failure; Renal toxicity; superoxide dismutase; Toxicology; urea
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2013.05.005

•Effect of phosphatidylcholine in cisplatin-induced nephrotoxicity was studied in rat model.•Cisplatin-induced nephrotoxicity was evaluated by serum BUN, creatinine and oxidative stress markers.•Phosphatidylcholine ameliorated cisplatin-induced serum BUN, creatinine and oxidative stress increases.•Phosphatidylcholine may have protective effect against cisplatin-induced nephrotoxicity. Although cisplatin is widely used in the treatment of cancers, clinical use of cisplatin is limited due to its nephrotoxicity. Pathophysiological mechanism of cisplatin-induced renal toxicity is a complex process and has not been fully understand. Reactive oxygen species (ROS) and oxidative stress have been presumed to be involved in this damage process. Phosphatidylcholine (PC) has antioxidant effect and prevents oxidative stress. Therefore, the present study aimed to investigate potential protective effects of PC on cisplatin-induced renal damage in rat. We examined the protective effects of PC on cisplatin-induced renal damage by assessment of serum creatinine, BUN, lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, superoxide dismutase activity and histophathological changes. PC ameliorated cisplatin-induced increases in serum creatinine, urea and oxidative stress. PC also decreased tubular degeneration and hypertrophy of glomeruli. PC may have a protective effect against cisplatin-induced nephrotoxicity in rats via enhancing antioxidant enzyme activity.