The response of glandular gastric transcriptome to T-2 toxin in chicks

This study was conducted to determine the effect of T-2 toxin on the transcriptome of the glandular stomach in chicks using RNA-sequencing (RNA-Seq). Four groups of 1-day-old Cobb male broilers (n = 4 cages/group, 6 chicks/cage) were fed a corn-soybean-based diet (control) and control supplemented w...

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Bibliographic Details
Published in:Food and chemical toxicology 2019-10, Vol.132, p.110658, Article 110658
Main Authors: Luo, Jing-Jing, Zhang, Yu, Sun, Hua, Wei, Jin-Tao, Khalil, Mahmoud Mohamed, Wang, You-Wei, Dai, Jie-Fan, Zhang, Ni-Ya, Qi, De-Sheng, Sun, Lv-Hui
Format: Article
Language:English
Subjects:
Chick
Gene expression
Glandular stomach
RNA-Seq
T-2 toxin
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Summary:This study was conducted to determine the effect of T-2 toxin on the transcriptome of the glandular stomach in chicks using RNA-sequencing (RNA-Seq). Four groups of 1-day-old Cobb male broilers (n = 4 cages/group, 6 chicks/cage) were fed a corn-soybean-based diet (control) and control supplemented with T-2 toxin at 1.0, 3.0, and 6.0 mg/kg, respectively, for 2 weeks. The histological results showed that dietary supplementation of T-2 toxin at 3.0 and 6.0 mg/kg induced glandular gastric injury including serious inflammation, increased inflammatory cells, mucosal edema, and necrosis and desquamation of the epithelial cells in the glandular stomach of chicks. RNA-Seq analysis revealed that there were 671, 1393, and 1394 genes displayed ≥2 (P 
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2019.110658