Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung

• Published in: FEBS Letters 2004-07, Vol.569 (1-3), p.1-6
• Main Authors: Kinnula, Vuokko L, Pääkkö, Paavo, Soini, Ylermi
• Format: Article
• Language: English
• Subjects: Antioxidant; Antioxidants - metabolism; AOE, antioxidant enzyme; Cancer; CAT, catalase; Catalase - metabolism; CuZnSOD, copper–zinc superoxide dismutase; CYTP450ox, cytochrome P450 oxidase; Disease Progression; ECSOD, extracellular superoxide dismutase; G-6-P-D, glucose-6-phosphate dehydrogenase; Glutamate-Cysteine Ligase - metabolism; GPX, glutathione peroxidase; GR, glutathione reductase; GRX, glutaredoxin; GS, glutathione synthase; GSH, reduced glutathione; GSSG, oxidized glutathione; GST, glutathione-S-transferase; GT, glutamyl transpeptidase; H2O2, hydrogen peroxide; HIF, hypoxia-inducible factor; HOBr, hypobromide; HOCl, hypochloride; Humans; Lung Neoplasms - enzymology; Lung Neoplasms - pathology; Malignancy; MITO, mitochondria; MMP, matrix methalloproteinase; MnSOD, manganese superoxide dismutase; MRP, multidrug resistance protein; NADPHox, NADPH oxidase; NO, nitric oxide; O2 −, superoxide radical; OH▪, hydroxyl radical; ONOO−, peroxynitrite; Oxidation-Reduction; Peroxidases - metabolism; Peroxiredoxins; PRX, peroxiredoxin; Reactive oxygen species; Redox; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSS, reactive sulphur species; SOD, superoxide dismutase; Superoxide Dismutase - metabolism; TGFβ, transforming growth factor beta; Thioredoxins - metabolism; TRX, thioredoxin; VEGF, vascular endothelial growth factor; XAO, xanthine oxidase; γGCS, gamma glutamyl cysteinyl synthetase
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/j.febslet.2004.05.045

Oxidants are known to modulate cell proliferation and apoptosis, and induce synthesis of growth factors that play an important role in tumor growth and invasion. Antioxidant enzymes and thiol proteins regulating cellular redox state constitute the major cellular protection against oxidants. Consequently, they are also associated both with carcinogenesis and tumor progression. Superoxide dismutases, glutamate cysteine ligase, catalase, thioredoxins and peroxiredoxins, which are the most important of these enzymes, are expressed in lung malignancies, and especially in pleural mesothelioma. This has consequences not only for tumor behavior but also for resistance of tumor cells to cytotoxic drugs and radiation.