Differential effect of NF-κB activity on β-catenin/Tcf pathway in various cancer cells

β-Catenin/Tcf and NF-κB pathways play an important role in biological functions. We determined the underlying mechanisms of differential interaction between two pathways in various human cancer cell lines. NF-κB positively regulated β-catenin/Tcf pathways in human glioblastoma, whereas it has an opp...

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Bibliographic Details
Published in:FEBS letters 2008-03, Vol.582 (5), p.616-622
Main Authors: Cho, Hyun Hwa, Song, Ji Sun, Yu, Ji Min, Yu, Sung Sook, Choi, Sung Jong, Kim, Dong Heon, Jung, Jin Sup
Format: Article
Language:English
Subjects:
Cancer cell
Lucine zipper tumor suppressor 2
NF-κB
β-Catenin/Tcf
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Summary:β-Catenin/Tcf and NF-κB pathways play an important role in biological functions. We determined the underlying mechanisms of differential interaction between two pathways in various human cancer cell lines. NF-κB positively regulated β-catenin/Tcf pathways in human glioblastoma, whereas it has an opposite effect on β-catenin/Tcf pathways in colon, liver, and breast cancer cells. Expression of lucine zipper tumor suppressor 2 (lzts2) was positively regulated by NF-κB activity in colon, liver, and breast cancer cells, whereas negatively regulated in glioma cells. Downregulation of lzts2 increased the β-catenin/Tcf promoter activity and inhibited NF-κB-induced modulation of the nuclear translocation of β-catenin. These data indicate that the differential crosstalk between β-catenin/Tcf and NF-κB pathway in various cancer cells is resulted from the differences in the regulation of NF-κB-induced lzts2 expression.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2008.01.029