Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes

The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0....

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Bibliographic Details
Published in:Fitoterapia 2005-09, Vol.76 (6), p.556-561
Main Authors: PSOTOVA, J, CHLOPCIKOVA, S, MIKETOVA, P, SIMANEK, V
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic
Biological and medical sciences
Cardiomyocyte
Cardiotonic Agents - administration & dosage
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Chemoprotection
Cinnamates - administration & dosage
Cinnamates - pharmacology
Cinnamates - therapeutic use
Depsides
Dose-Response Relationship, Drug
Doxorubicin
Female
General pharmacology
Male
Medical sciences
Myocytes, Cardiac - drug effects
Oxidative Stress
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Prunella
Prunella vulgaris
Rats
Rats, Sprague-Dawley
Rosmarinic Acid
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Summary:The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml and the effect of PVEF correlated with the RA content. Dexrazoxan (DE), used as positive control, was less effective than PVEF or RA.
ISSN:0367-326X
DOI:10.1016/j.fitote.2005.04.019