Antinociceptive effect of Hyptis pectinata leaves extracts

Oral administration of hexanes, chloroform, and ethyl acetate extracts of the leaves of Hyptis pectinata significantly reduced the number of writhing induced by acetic acid and increased the response to thermal stimuli in hot-plate test. Such effect was completely reversed by the opioid antagonist n...

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Bibliographic Details
Published in:Fitoterapia 2006-09, Vol.77 (6), p.439-442
Main Authors: Lisboa, Ana C.C.D., Mello, Iderjane C.M., Nunes, Rogeria S., dos Santos, Marquês A., Antoniolli, Angelo R., Marçal, Rosilene M., Cavalcanti, Sócrates C. de H.
Format: Article
Language:English
Subjects:
Acetic Acid
Analgesics - administration & dosage
Analgesics - pharmacology
Analgesics - therapeutic use
Analgesy
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Female
General pharmacology
Hot Temperature
Hyptis
Hyptis pectinata
Male
Medical sciences
Mice
Naloxone
Pain - chemically induced
Pain - prevention & control
Pain Measurement - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
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Summary:Oral administration of hexanes, chloroform, and ethyl acetate extracts of the leaves of Hyptis pectinata significantly reduced the number of writhing induced by acetic acid and increased the response to thermal stimuli in hot-plate test. Such effect was completely reversed by the opioid antagonist naloxone.
ISSN:0367-326X
DOI:10.1016/j.fitote.2006.06.001