Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins

The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba maté ( Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylgly...

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Bibliographic Details
Published in:Fitoterapia 2009-09, Vol.80 (6), p.339-344
Main Authors: Gugliucci, A., Bastos, Deborah H. Markowicz, Schulze, John, Souza, Marina F. Ferreira
Format: Article
Language:English
Subjects:
Glycation
Ilex paraguariensis
Nutraceutical
Phenolic acids
Saponin
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Summary:The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba maté ( Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylglyoxal with or without the addition of 5-caffeoylquinic acid, caffeic acid and oleanolic acid. After the incubation period, advanced glycation end product (AGE) fluorescence spectra were performed and protein structural changes were evaluated by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis. Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of maté tea. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2009.04.007