Rapid profiling and target analysis of principal components in Fuling Decoctions by UFLC-DAD-ESI-MS

The traditional Chinese medicine formula Fuling Decoction (FD) has been clinically used for eczema treatment, but the unclear chemical distribution and the lack of quality control have strongly restricted its application. In this study, an analytical method incorporating ultra-fast liquid chromatogr...

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Bibliographic Details
Published in:Fitoterapia 2010-09, Vol.81 (6), p.662-667
Main Authors: Wang, Ao-Xue, Ge, Guang-Bo, Qi, Xiao-Yi, Hu, Ying, Liang, Si-Cheng, Yang, Ling, Tu, Cai-Xia
Format: Article
Language:English
Subjects:
Fuling Decoction
Genipingentiobioside
Geniposide
Liquiritin
Paeoniflorin
UFLC-DAD-ESI-MS
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Summary:The traditional Chinese medicine formula Fuling Decoction (FD) has been clinically used for eczema treatment, but the unclear chemical distribution and the lack of quality control have strongly restricted its application. In this study, an analytical method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for rapid profiling of the chemical constitutes from FD. Fourteen constitutes were identified by UFLC-ESI-MS, while four major components including genipingentiobioside, geniposide, paeoniflorin and liquiritin were quantified simultaneously by UFLC-DAD. The UFLC-based method was fully validated and can be applied to screening and determination of principal components in commercially FD prescriptions. Genipingentiobioside, geniposide, paeoniflorin and liquiritin were identified as principal constitutes in Fuling Decoction. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2010.03.016