(−)-α-Bisabolol attenuates visceral nociception and inflammation in mice

• Published in: Fitoterapia 2011-03, Vol.82 (2), p.208-211
• Main Authors: Leite, Gerlânia de O., Leite, Laura H.I., Sampaio, Renata de S., Araruna, Mariana Késsia A., de Menezes, Irwin Rose A., da Costa, José Galberto M., Campos, Adriana R.
• Format: Article
• Language: English
• Subjects: animal models; anti-inflammatory activity; arachidonic acid; Biological and medical sciences; Croton; cyclophosphamide; dermatitis; Ear edema; ears; General pharmacology; inflammation; Medical sciences; mice; mustard oil; nociception; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phenol; Visceral nociception; α-bisabolol
• ISSN: 0367-326X
• DOI: 10.1016/j.fitote.2010.09.012

The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (−)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent. (−)-α-Bisabolol is effective topical antiinflammatory agent in the experimental models of acute dermatitis and inhibits visceral nociception induced by cyclophosphamide and mustard oil [Display omitted]