Minor pregnanes from Caralluma adscendens var. gracilis and Caralluma pauciflora

Phytochemical investigation of Caralluma adscendens var. gracilis and Caralluma pauciflora (Asclepiadaceae) whole plant extracts allowed to isolate one pregnane glycoside and two pregnanes characterized as 12β,20-O-dibenzoyl-5α,6-dihydrosarcostin β-oleandropyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-d...

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Bibliographic Details
Published in:Fitoterapia 2011-10, Vol.82 (7), p.1039-1043
Main Authors: Reddy, Kommidi Devendar, Rao, Belvotagi Venkatrao Adavi, Babu, Gummadi Sridhar, Kumar, Bobbala Ravi, Braca, Alessandra, Vassallo, Antonio, De Tommasi, Nunziatina, Rao, Ghanakota Venkateshwar, Rao, Achanta Venkata Narasimha Appa
Format: Article
Language:English
Subjects:
Asclepiadaceae
Biological and medical sciences
Caralluma
Caralluma adscendens var. gracilis
Caralluma pauciflora
General pharmacology
glycosides
lupeol
Medical sciences
nuclear magnetic resonance spectroscopy
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
plant extracts
Pregnanes
Spectral analysis
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Summary:Phytochemical investigation of Caralluma adscendens var. gracilis and Caralluma pauciflora (Asclepiadaceae) whole plant extracts allowed to isolate one pregnane glycoside and two pregnanes characterized as 12β,20-O-dibenzoyl-5α,6-dihydrosarcostin β-oleandropyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-digitoxypyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-cymaropyranoside (1), 12β-O-benzoyl-3β,11α,14β,20R-pentahydroxy-pregn-5-ene (2), and 11α-O-benzoyl-3β,12β,14β,20R-pentahydroxy-pregn-5-ene (3), respectively. Their structural characterization was obtained on the basis of extensive NMR spectral studies. Three known pregnane glycosides along with lupeol and β-sitosterol were also isolated and characterized. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2011.06.011