Formylated phloroglucinols from Eucalyptus loxophleba foliage

Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1–7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ss...

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Bibliographic Details
Published in:Fitoterapia 2011-10, Vol.82 (7), p.1118-1122
Main Authors: Sidana, Jasmeen, Singh, Sukhvinder, Arora, Sunil Kumar, Foley, William J., Singh, Inder Pal
Format: Article
Language:English
Subjects:
Antileishmanial
Biological and medical sciences
Eucalyptus
Eucalyptus loxophleba
Euglobals
Formylated phloroglucinols
General pharmacology
Grandinal
leaves
Leishmania donovani
Loxophlebal A
Medical sciences
nuclear magnetic resonance spectroscopy
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
spectral analysis
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Summary:Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1–7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2011.07.009