Antibacterial dihydrobenzopyran and xanthone derivatives from Garcinia cowa stem barks

Two new compounds, garciniacowol (1) and garciniacowone (2) along with 15 known compounds were isolated from the stem barks of Garcinia cowa. Their structures were determined by intensive spectroscopic methods. The structure of 1 was a symmetrical dimeric dihydrobenzopyran derivative, whereas the fr...

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Bibliographic Details
Published in:Fitoterapia 2012-12, Vol.83 (8), p.1430-1434
Main Authors: Siridechakorn, Ittipon, Phakhodee, Wong, Ritthiwigrom, Thunwadee, Promgool, Trinop, Deachathai, Suwanna, Cheenpracha, Sarot, Prawat, Uma, Laphookhieo, Surat
Format: Article
Language:English
Subjects:
Antibacterial activity
antibacterial properties
Biological and medical sciences
Clusiaceae
Dimeric chroman
Escherichia coli
Garcinia
Garcinia cowa
General pharmacology
Medical sciences
minimum inhibitory concentration
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rearranged triprenylxanthone
Salmonella typhimurium
spectroscopy
Staphylococcus aureus
xanthone
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Summary:Two new compounds, garciniacowol (1) and garciniacowone (2) along with 15 known compounds were isolated from the stem barks of Garcinia cowa. Their structures were determined by intensive spectroscopic methods. The structure of 1 was a symmetrical dimeric dihydrobenzopyran derivative, whereas the framework of 2 was a triprenyl caged-xanthone precursor. The antibacterial activities against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466, and methicillin-resistant S. aureus (MRSA) SK1 of the isolated compounds were also evaluated. Compounds 2 and 9 exhibited good antibacterial activity against MRSA SK1 with the same minimum inhibitory concentration (MIC) value of 2μg/mL. Moreover, compound 2 also showed good antibacterial activity against S. aureus with an MIC value of 2μg/mL. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2012.08.006