Antioxidant xanthones from Swertia mussotii, a high altitude plant

Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-β-d-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(β-d-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(β-d-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(β-d-glucoside) (4), together with twenty-one known xanthones (5–25) were isol...

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Bibliographic Details
Published in:Fitoterapia 2013-12, Vol.91, p.140-147
Main Authors: Luo, Cui-Ting, Mao, Shuang-Shuang, Liu, Fang-Lan, Yang, Mao-xun, Chen, Heru, Kurihara, Hiroshi, Li, Yulin
Format: Article
Language:English
Subjects:
altitude
Antioxidant
antioxidants
ethanol
ORAC
oxygen radical absorbance capacity
spectroscopy
Swertia
Swertia L
Swertia mussotii
Xanthones
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Summary:Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-β-d-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(β-d-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(β-d-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(β-d-glucoside) (4), together with twenty-one known xanthones (5–25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORACFL assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where 1 is the most active compound and 13 is the least one. A preliminary structure–activity relationship is also discussed. Four new xanthones, together with 21 known xanthones have been isolated from Swertia mussotii. Antioxidant capacity of all compounds was evaluated by ORACFL assay. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2013.08.021