Bis-spirolabdane diterpenoids from Leonurus japonicus and their anti-platelet aggregative activity

Six bis-spirolabdane diterpenoids along with four known analogues were isolated from the aerial parts of Leonurus japonicus. Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and a modified Mosher's method. The inhibitory a...

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Bibliographic Details
Published in:Fitoterapia 2015-01, Vol.100, p.1-6
Main Authors: Xiong, Liang, Zhou, Qin-Mei, Peng, Cheng, Xie, Xiao-Fang, Liu, Lu-Si, Guo, Li, He, Ya-Cong, Yang, Lian, Liu, Zhao-Hua
Format: Article
Language:English
Subjects:
Absolute configuration
Anti-platelet aggregative activity
Bis-spirolabdane diterpenoids
Leonurus japonicus
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Summary:Six bis-spirolabdane diterpenoids along with four known analogues were isolated from the aerial parts of Leonurus japonicus. Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and a modified Mosher's method. The inhibitory activity of the compounds against the abnormal increase in platelet aggregation induced by adenosine diphosphate was investigated. Only the (13R)-bis-spirolabdane diterpenoids exhibited a significant effect. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2014.11.003