Stachybisbins A and B, the first cases of seco-bisabosquals from Stachybotrys bisbyi

Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, together with three biogenetically related metabolites (3–5), were isolated from a wetland fungal strain of Stachybotrys bisbyi. The structures of the new compounds were determined by spectroscopic an...

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Bibliographic Details
Published in:Fitoterapia 2015-09, Vol.105, p.151-155
Main Authors: Bao, Yan-Ru, Chen, Guo-Dong, Wu, Yue-Hua, Li, Xiao-Xia, Hu, Dan, Liu, Xing-Zhong, Li, Yan, Yao, Xin-Sheng, Gao, Hao
Format: Article
Language:English
Subjects:
Cytotoxic activities
Hypocreales
Meroterpenoid
Seco-bisabosqual
Stachybotrys bisbyi
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Summary:Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, together with three biogenetically related metabolites (3–5), were isolated from a wetland fungal strain of Stachybotrys bisbyi. The structures of the new compounds were determined by spectroscopic analyses, modified Mosher's method, and quantum chemical CD method. The cytotoxic activities of all compounds were tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines. Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, were isolated from a wetland fungal strain of Stachybotrys bisbyi. Their structures were determined by spectroscopic analyses, modified Mosher’s method, and quantum chemical CD method. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2015.06.022