Two new polyketides from the roots of Stemona tuberosa

Two polyketides, stemonones A (1) and B (2) with new skeletons, were isolated from the roots of Stemona tuberosa. Their absolute structures were fully characterized by comprehensive spectroscopic analyses and comparison of experimental electronic circular dichroism (ECD) spectra with calculated ones...

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Bibliographic Details
Published in:Fitoterapia 2018-09, Vol.129, p.150-153
Main Authors: Fang, Lei, Song, Xiu-Qing, He, Tian-Tian, Zhu, Kong-Kai, Yu, Jin-Hai, Song, Jin-Tong, Zhou, Jie, Zhang, Hua
Format: Article
Language:English
Subjects:
Anti-inflammation
Polyketides
Stemona tuberosa
Stemonaceae
Stemonone
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Summary:Two polyketides, stemonones A (1) and B (2) with new skeletons, were isolated from the roots of Stemona tuberosa. Their absolute structures were fully characterized by comprehensive spectroscopic analyses and comparison of experimental electronic circular dichroism (ECD) spectra with calculated ones. The plausible biosynthetic pathways for 1 and 2 were also proposed. Anti-inflammatory assay confirmed that the two compounds showed moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2018.06.025