Rare noreudesmane sesquiterpenoids from the fruits of Dysoxylum densiflorum

Seven rare noreudesmane sesquiterpenoids (dysoxydenones M-S, 1–7), including three 11,12,13-trinoreudesmanes, three 13-noreudesmanes and one spirovetivane-type sesquiterpenoid, along with two known analogues were isolated from the fruits of Dysoxylum densiflorum. The planar structures were elucidate...

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Bibliographic Details
Published in:Fitoterapia 2023-04, Vol.166, p.105462, Article 105462
Main Authors: Hua, Wang, Wang, Xiaoli, Li, Qianqian, Li, Yaqi, Cui, Letian, Li, Yongyi, Kong, Lingyi, Luo, Jun
Format: Article
Language:English
Subjects:
CD exciton chirality method
Noreudesmane
Single-crystal X-ray method
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Summary:Seven rare noreudesmane sesquiterpenoids (dysoxydenones M-S, 1–7), including three 11,12,13-trinoreudesmanes, three 13-noreudesmanes and one spirovetivane-type sesquiterpenoid, along with two known analogues were isolated from the fruits of Dysoxylum densiflorum. The planar structures were elucidated by a combination of 1D, 2D NMR and HRESIMS analyses. Their absolute configurations were determined by combination of single-crystal X-ray diffraction, CD exciton chirality method and ECD calculation. All compounds were screened for anti-inflammatory activity on LPS-induced RAW 264.7 cells and IL-1β inhibitory activity. [Display omitted] •Seven rare noreudesmane sesquiterpenoids were isolated from fruits of Dysoxylum densiflorum.•Compounds 1‐3 were 11,12,13-trinoreudesmanes, 4–6 were rare 13-noreudesmanes, and 7 was spirovetivane-type sesquiterpenoid.•Their absolute configurations were determined by single-crystal X-ray diffraction and CD exciton chirality method.
ISSN:0367-326X
DOI:10.1016/j.fitote.2023.105462